1383970-05-5Relevant articles and documents
Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Bayomi, Said M.,El-Kashef, Hassan A.,El-Ashmawy, Mahmoud B.,Nasr, Magda N. A.,El-Sherbeny, Magda A.,Badria, Farid A.,Abou-Zeid, Laila A.,Ghaly, Mariam A.,Abdel-Aziz, Naglaa I.
, p. 1147 - 1162 (2013/04/10)
Twenty-four new compounds were prepared, taking curcumin as a lead, in order to explore their antioxidant and antitumor properties. The capacities of these derivatives to scavenge the 2,2′-azinobis(3-ethylbenzothiazoline-6- sulfonic acid) radical cation (ABTS.+), and to protect human red blood cells (RBCs) from oxidative haemolysis were investigated. In addition, the percentage viability of different cell lines (Hep G2, WI38, VERO and MCF-7) was tested. The result of the antitumor testing was generally in accordance with those of the antioxidant assays. Compounds which bear o-methoxy substitution to the 4-hydroxy function in the phenyl ring (7g, 5g and 3g) exhibited significantly higher ABTS.+-scavenging, antihaemolysis, and antitumor activities than other derivatives. In addition, molecular modelling studies were carried out for biologically active and inactive compounds, to study the structure-activity relationship, with the aim to elucidate which portions of the molecules are critical for the antioxidant and antitumor activity.
