Welcome to LookChem.com Sign In|Join Free
  • or

138402-10-5

Post Buying Request

138402-10-5 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Trityl Irbesartan Manufacturer/High quality/Best price/In stock
Cas No: 138402-10-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Pharmaceutical Raw Material Irbesartan intermediates with GMP/EDMF
Cas No: 138402-10-5
USD $ 3.0-3.0 / Gram 1 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Factory supply high quality Trityl Irbestartan,138402-10-5
Cas No: 138402-10-5
No Data No Data Metric Ton/Day Hubei Taiho Chemical Co.,LTD Contact Supplier
8-butyl-7-[[4-[2-[2-(triphenylmethyl)-5-tetrazolyl]phenyl]phenyl]methyl]-7,9-diazaspiro[4.4]non-8-en-6-one
Cas No: 138402-10-5
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2-Butyl-3-[[4-[2-(2-trityl-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Cas No: 138402-10-5
No Data 1 Kilogram 1000 Kilogram/Month Shanghai Bokchang Chemical Science and Technology Co.,Ltd Contact Supplier
Trityl irbesartan
Cas No: 138402-10-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
C44H42N6O Trityl Irbesartan 138402-10-5
Cas No: 138402-10-5
No Data 1 Metric Ton 100 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 138402-10-5 with competitive price
Cas No: 138402-10-5
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
High quality Trityl Irbesartan
Cas No: 138402-10-5
USD $ 1.0-2.0 / Kilogram 10 Kilogram 50 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier
Trityl Irbesartan 138402-10-5
Cas No: 138402-10-5
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier

138402-10-5 Usage

Uses

Irbesartan (I751000) derivative.
InChI:InChI=1/C44H42N6O/c1-2-3-25-40-45-43(30-15-16-31-43)42(51)49(40)32-33-26-28-34(29-27-33)38-23-13-14-24-39(38)41-46-47-48-50(41)44(35-17-7-4-8-18-35,36-19-9-5-10-20-36)37-21-11-6-12-22-37/h4-14,17-24,26-29H,2-3,15-16,25,30-32H2,1H3

138402-10-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Triphenylmethyl Irbesartan

1.2 Other means of identification

Product number -
Other names 2-butyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138402-10-5 SDS

138402-10-5Synthetic route

3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
731851-41-5

3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid; palladium diacetate; triphenylphosphine In tetrahydrofuran; 1,2-dimethoxyethane at 20℃; for 0.666667h;
Stage #2: 3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one With water; potassium carbonate In tetrahydrofuran; 1,2-dimethoxyethane at 20 - 80℃; for 3.5h; Heating / reflux;
90%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.0194444h; microwave irradiation;90%
2-(2-thienyl)-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diazaspiro[4.4]non-1-en-4-one
1199814-94-2

2-(2-thienyl)-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diazaspiro[4.4]non-1-en-4-one

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
With hydrogen; Raney nickel In N,N-dimethyl-formamide at 20℃;88%
3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
731851-41-5

3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid
144873-97-2

2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
With potassium carbonate; palladium diacetate; triphenylphosphine In water; toluene at 95 - 100℃; for 3 - 4h; Product distribution / selectivity;80%
With caesium carbonate; palladium diacetate; triphenylphosphine In water; toluene at 95 - 100℃; for 3 - 4h; Product distribution / selectivity;80%
With potassium hydroxide; palladium diacetate; triphenylphosphine In water; toluene at 95 - 100℃; for 3 - 4h; Product distribution / selectivity;72%
N-pentanoylaminocyclopentane-1-carboxylic acid
15026-80-9

N-pentanoylaminocyclopentane-1-carboxylic acid

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine
134603-82-0

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: N-pentanoylaminocyclopentane-1-carboxylic acid; 1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine With methanesulfonic acid In toluene at 20℃; for 48h; Heating / reflux;
Stage #2: With sodium hydroxide In water; ethyl acetate for 0.5h;
80%
Stage #1: N-pentanoylaminocyclopentane-1-carboxylic acid; 1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine With methanesulfonic acid In toluene at 20℃; for 48h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate for 0.5h;
80%
2-n-butyl-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-1,3-diazaspiro[4.4]non-1-ene-4-one
894806-38-3

2-n-butyl-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-1,3-diazaspiro[4.4]non-1-ene-4-one

N-trityl-5-(2-bromophenyl)tetrazole
143945-72-6

N-trityl-5-(2-bromophenyl)tetrazole

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: With triphenylphosphine; palladium diacetate In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 2-n-butyl-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-1,3-diazaspiro[4.4]non-1-ene-4-one; N-trityl-5-(2-bromophenyl)tetrazole With potassium phosphate In tetrahydrofuran for 48h; Product distribution / selectivity; Heating / reflux;
54%
With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran for 48h; Product distribution / selectivity; Heating / reflux;32%
1-(1'-ethoxy)pentanaminylcyclopentent carboxylate
745814-10-2

1-(1'-ethoxy)pentanaminylcyclopentent carboxylate

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine
134603-82-0

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
acetic acid In toluene for 3h; Heating / reflux;50%
4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]phenylboronic acid
894806-37-2

4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]phenylboronic acid

N-trityl-5-(2-bromophenyl)tetrazole
143945-72-6

N-trityl-5-(2-bromophenyl)tetrazole

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In water; ethyl acetate; N,N-dimethyl-formamide; toluene at 85℃; for 48h; Product distribution / selectivity;50%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene for 5 - 6h; Suzuki Coupling; Heating / reflux;
With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 120℃; for 6h;
1-(pentanoylamino)cyclopentanecarboxamide
177219-40-8

1-(pentanoylamino)cyclopentanecarboxamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
With sodium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In toluene at 50 - 90℃; for 4h;32%
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h;
C13H23NO3
745814-11-3

C13H23NO3

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine
134603-82-0

1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: C13H23NO3 With 2,6-dimethylpyridine; oxalyl dichloride In toluene at 0℃; for 1h;
Stage #2: 1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methanamine In toluene at 0 - 20℃; for 1h;
30%
N-pentanoyl-N-[[2'-[N-(triphenylmethyl)tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl]amine
439904-79-7

N-pentanoyl-N-[[2'-[N-(triphenylmethyl)tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl]amine

ethyl 1-aminocyclopentanecarboxylate
1664-35-3

ethyl 1-aminocyclopentanecarboxylate

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: N-pentanoyl-N-[[2'-[N-(triphenylmethyl)tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl]amine With 2,6-dimethylpyridine; oxalyl dichloride In toluene at 0℃; for 1h;
Stage #2: ethyl 1-aminocyclopentanecarboxylate In toluene at 0 - 20℃; for 1h;
25%
2-(1-TRITYL-1H-TETRAZOL-5-YL)-4'-(1''-ETHOXYPENTANAMINYL)BIPHENYL
745814-08-8

2-(1-TRITYL-1H-TETRAZOL-5-YL)-4'-(1''-ETHOXYPENTANAMINYL)BIPHENYL

ethyl 1-aminocyclopentanecarboxylate
1664-35-3

ethyl 1-aminocyclopentanecarboxylate

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: 2-(1-TRITYL-1H-TETRAZOL-5-YL)-4'-(1''-ETHOXYPENTANAMINYL)BIPHENYL; ethyl 1-aminocyclopentanecarboxylate In toluene at 20℃; for 2h;
Stage #2: acetic acid In toluene for 5h; Heating / reflux;
20%
5-(4-(bromomethyl)-[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole

5-(4-(bromomethyl)-[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one
138402-05-8

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In acetonitrile at 31 - 40℃; for 2.5h; Product distribution / selectivity;
trityl chloride
76-83-5

trityl chloride

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
138401-24-8

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
Stage #1: 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile With tributyltin azide In xylene for 66h; Heating / reflux;
Stage #2: trityl chloride With sodium hydroxide In tetrahydrofuran; dichloromethane; water for 26h;
Stage #1: 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile With sodium azide; tributyltin chloride; tetrabutylammomium bromide In toluene for 20h; Heating / reflux;
Stage #2: With acetic acid In water; toluene at 20℃; for 0.25h;
Stage #3: trityl chloride With triethylamine In dichloromethane at 25 - 30℃; for 2h;
trityl irbesartan
138402-10-5

trityl irbesartan

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: trityl irbesartan With hydrogenchloride In water; acetone at 35 - 45℃; for 1.5 - 2h;
Stage #2: In water; acetone at 15℃; pH=11 - 13; Alkaline aqueous solution;
98.75%
With sulfuric acid In water; acetone at 35 - 40℃; for 7h;93%
With sodium hydroxide In methanol at 20℃;87%
trityl irbesartan
138402-10-5

trityl irbesartan

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride sesquihydrate

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride sesquihydrate

Conditions
ConditionsYield
With hydrogenchloride; water In toluene at 55℃; for 1h; Product distribution / selectivity;95%
trityl irbesartan
138402-10-5

trityl irbesartan

A

methoxytriphenylmethane
596-31-6

methoxytriphenylmethane

B

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: trityl irbesartan With hydroxylamine hydrochloride In methanol; water; acetone at 20℃; for 2h;
Stage #2: With sodium hydroxide In methanol; water; acetone at 20 - 25℃; pH=3.8 - 12.5;
A n/a
B 91%
Stage #1: trityl irbesartan With hydroxylamine hydrochloride In methanol; water; isopropyl alcohol; acetone at 20℃; for 2h;
Stage #2: With sodium hydroxide In methanol; water; acetone at 20 - 25℃; pH=12.0 - 12.5;
A n/a
B 89%
methanol
67-56-1

methanol

trityl irbesartan
138402-10-5

trityl irbesartan

A

methoxytriphenylmethane
596-31-6

methoxytriphenylmethane

B

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
for 10h; Heating / reflux;A 73%
B 71%
trityl irbesartan
138402-10-5

trityl irbesartan

2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one hydrobromide
329055-24-5

2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; water at 20℃; for 3h;
trityl irbesartan
138402-10-5

trityl irbesartan

A

triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

B

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With hydrogenchloride; water In acetone
trityl irbesartan
138402-10-5

trityl irbesartan

2-n-butyl-4-spirocyclopentane-1-[((2'-tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride
329055-23-4

2-n-butyl-4-spirocyclopentane-1-[((2'-tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride

Conditions
ConditionsYield
Stage #1: trityl irbesartan With methanol; potassium hydroxide for 2.5h; Heating / reflux;
Stage #2: With hydrogenchloride In water at 20℃; for 4h; pH=0.99; Product distribution / selectivity;
Stage #1: trityl irbesartan With methanol; toluene-4-sulfonic acid In thioguanin for 24h; Heating / reflux;
Stage #2: With sodium hydroxide In water pH=12.7;
Stage #3: With hydrogenchloride; sodium hydroxide Product distribution / selectivity; more than 3 stages;
With hydrogenchloride In ethanol; water at 20℃; for 3h; Product distribution / selectivity;

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields