138407-94-0Relevant academic research and scientific papers
Tuning of α-Silyl Carbocation Reactivity into Enone Transposition: Application to the Synthesis of Peribysin D, E-Volkendousin, and E-Guggulsterone
Athawale, Paresh R.,Zade, Vishal M.,Rama Krishna, Gamidi,Reddy, D. Srinivasa
, p. 6642 - 6647 (2021/09/02)
A reliable method for enone transposition has been developed with the help of silyl group masking. Enantio-switching, substituent shuffling, and Z-selectivity are the highlights of the method. The developed method was applied for the first total synthesis of peribysin D along with its structural revision. Formal synthesis of E-guggulsterone and E-volkendousin was also claimed using a short sequence.
Platinum catalysed hydrosilylation of propargylic alcohols
McAdam, Catherine A.,McLaughlin, Mark G.,Johnston, Adam J. S.,Chen, Jun,Walter, Magnus W.,Cook, Matthew J.
, p. 4488 - 4502 (2013/08/23)
A facile and user-friendly protocol has been developed for the selective synthesis of E-vinyl silanes derived from propargylic alcohols using a PtCl 2/XPhos catalyst system. The reaction is generally high yielding and provides a single regioiso
PtCl2/XPhos: A highly efficient and readily available catalyst for the hydrosilylation of propargylic alcohols
McLaughlin, Mark G.,Cook, Matthew J.
supporting information; experimental part, p. 11104 - 11106 (2011/11/07)
A highly regioselective hydrosilylation of propargylic alcohols has been developed using an in situ prepared PtCl2/XPhos catalyst system. The reaction is tolerant of many functional groups and exhibits excellent regio and geometric selectivity.
Exploring the Reactivity of Alkenes Bearing Silicon and/or Tin in the Hydroxyl-Directed Hydrogenation. A Diastereoselective Synthesis of Heterobimetallic Compounds
Lautens, Mark,Zhang, C. H.,Goh, Betty Jane,Crudden, Cathleen M.,Johnson, Marc J. A.
, p. 6208 - 6222 (2007/10/02)
The hydroxyl-directed hydrogenation of (E)- and (Z)-γ-hydroxy vinylstannanes and silanes has been studied in the presence of (dppb)Rh(NBD)BF4 (1).Efficient routes to γ-hydroxy stannanes and silanes vave been developed.Diastereoselectivities from 60 to >50
