1384100-12-2

Upstream product

• 90-02-8 salicylaldehyde 
• 15795-14-9 (E)-1-bromo-3-(2-nitrovinyl)benzene 
• 115665-95-7 3-bromo-β-nitro-styrene 

Downstream Products

• 1384100-20-2 (S)-2-(3-bromophenyl)-3-nitro-2H-chromene 
• 1384100-32-6 (R)-2-((2R,3R,4S)-2-(3-bromophenyl)-3-nitrochroman-4-yl)cyclohexanone 

Relevant academic research and scientific papers

Cascade Oxa-Michael-Henry Reaction of Salicylaldehydes with Nitrostyrenes via Ball Milling: A Solvent-Free Synthesis of 3-Nitro-2 H -chromenes

Cascade oxa-Michael-Henry reactions of salicylaldehyde derivatives with β-nitrostyrenes catalyzed by potassium carbonate via solvent-free ball milling are demonstrated. The corresponding 3-nitro-2H-chromene products were obtained in moderate to excellent yields. This method offers significant advantages, particularly in terms of high yields, short reaction times and mild conditions.

Augmentation of Enantioselectivity by Spatial Tuning of Aminocatalyst: Synthesis of 2-Alkyl/aryl-3-nitro-2 H-chromenes by Tandem Oxa-Michael-Henry Reaction

The asymmetric oxa-Michael addition of salicylaldehyde to conjugated nitroalkenes often suffers from poor reactivity and selectivity and a long reaction time. Because of the formation of an iminium ion with aminocatalyst, the nucleophilicity of the phenol