1384118-30-2Relevant academic research and scientific papers
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors
La Regina, Giuseppe,Coluccia, Antonio,Brancale, Andrea,Piscitelli, Francesco,Famiglini, Valeria,Cosconati, Sandro,Maga, Giovanni,Samuele, Alberta,Gonzalez, Emmanuel,Clotet, Bonaventura,Schols, Dominique,Esté, José A.,Novellino, Ettore,Silvestri, Romano
supporting information; experimental part, p. 6634 - 6638 (2012/10/08)
New indolylarylsulfone (IAS) derivatives bearing nitrogen containing substituents at the indole-2-carboxamide inhibited the HIV-1 WT in MT-4 cells at low nanomolar concentrations. In particular, compound 9 was uniformly effective against the mutant Y181C, Y188L, and K103N HIV-1 strains; it was highly active against the multidrug resistant mutant IRLL98 HIV-1 strain bearing the K101Q, Y181C, and G190A mutations conferring resistance to NVP, DLV, and EFV and several HIV-1 clades A in PBMC.
