138415-70-0Relevant articles and documents
A Versatile and Convenient Method for the Syntheses of Pyrimidothiazine and -thiazepine Ring Systems
Sako, Magoichi,Totani, Reiko,Konohara, Minako,Hirota, Kosaku,Maki, Yoshifumi
, p. 2675 - 2677 (2007/10/02)
Treatment of 5-hydroxyuracil 1 and 5-hydroxyisocytosine 2 with N-bromosuccinimide in ethanol followed by the thermal condensation with β- and γ-amino thiols such as 2-aminothiophenol, cysteamine, L-cysteine and D,L-homocysteine resulted in the formation of the corresponding pyrimidothiazin-4(3H)-ones, 3-8, and pyrimidothiazine and -thiazepine ring systems was shown to involve the condensation of 5,6-diethoxy-5-hydroxy-5,6-dihydropyrimidin-4(3H)-one intermediates, 11 and 12, with the β- and γ-amino thiols which is accelerated in the presence of an acid-catalyst.