1384176-08-2Relevant academic research and scientific papers
An organocatalytic direct Mannich-cyclization cascade as [3+2] annulation: Asymmetric synthesis of 2,3-substituted pyrrolidines
Kumar, Indresh,Mir, Nisar A.,Gupta, Vivek K.,Rajnikant
, p. 6975 - 6977 (2012/07/31)
A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%).
