1384176-90-2Relevant academic research and scientific papers
Divergent stereocontrol of acid catalyzed intramolecular aldol reactions of 2,3,7-triketoesters: Synthesis of highly functionalized cyclopentanones
Truong, Phong,Shanahan, Charles S.,Doyle, Michael P.
, p. 3608 - 3611 (2012/08/29)
The intramolecular acid catalyzed aldol cyclization of 2,3,7-triketoesters formed from Χ-keto-α-diazo-β-ketoesters provides highly functionalized cyclopentanones with good diastereoselectivity in high overall yields via kinetically controlled and stereodivergent catalytic processes. Lewis acid catalysis gives high selectivity for the 1,2-anti tetrasubstituted cyclopentanones, whereas Bronsted acid catalysis produces the corresponding 1,2-syn diastereomer.
