1384186-72-4Relevant academic research and scientific papers
Synthesis of isoquinoline alkaloids via oxidative amidation-bischler- napieralski reaction
Shankar,More, Satish S.,Madhubabu,Vembu,Syam Kumar
, p. 1013 - 1020 (2012/06/01)
A straightforward synthesis of -keto amides by coupling primary amines with aryl dibromoethanones under oxidative amidation conditions has been developed. The -keto amides were then subjected to heterocyclodehydration reaction under Bischler-Napieralski conditions followed by aromatization with DBU provided 1-benzoyl isoquinolines in a two-stage process. Utilizing this methodology, isoquinoline alkaloids such as thalmicrinone, papavaraldine, and pulcheotine A were synthesized in excellent yields. Georg Thieme Verlag Stuttgart · New York.
