138421-49-5

Basic information

• Product Name: Benzoyl fluoride, 2-methoxy- (9CI)
• Synonyms: Benzoyl fluoride, 2-methoxy- (9CI)
• CAS NO: 138421-49-5
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.1383832
• Product Categories: ACIDHALIDE
• Mol File: 138421-49-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl fluoride, 2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl fluoride, 2-methoxy- (9CI)(138421-49-5)
• EPA Substance Registry System: Benzoyl fluoride, 2-methoxy- (9CI)(138421-49-5)

Safety Data

• Hazardous Substances Data: 138421-49-5(Hazardous Substances Data)

Upstream product

• 578-57-4 2-bromoanisole 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 579-75-9 2-Methoxybenzoic acid 
• 201230-82-2 carbon monoxide 

Downstream Products

• 183198-63-2 N-benzyl-2-methoxylbenzamide 
• 100-66-3 methoxybenzene 
• 135-02-4 ortho-anisaldehyde 
• 754992-77-3 N-(6-(4-benzyloxyphenoxy)benzothiazol-2-yl)-N-(4-(3-(1,3-dihydro-1,3-dioxoisoindol-2-yl)propoxy)benzyl)-2-methoxybenzamide 

Relevant articles and documents

Catalytic Acid Fluoride Synthesis via Carbonylation of Organic Bromides in the Presence Potassium Fluoride

Various aryl bromides were carbonylated under an atmospheric pressure of carbon monoxide in DMF in the presence of potassium fluoride to give aroyl fluorides in excellent yields.The carbonylation was promoted by the addition of phase transfer catalysts, but the contamination with water reduced the selectivity.

METHOD AND REAGENT FOR DEOXYFLUORINATION

A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.

Deoxyfluorination of Carboxylic Acids with KF and Highly Electron-Deficient Fluoroarenes

A deoxyfluorination reaction of carboxylic acids using potassium fluoride (KF) and highly electron-deficient fluoroarenes is reported here, giving acyl fluorides in moderate to excellent yield (57-92% based on NMR integration and 34-95% for isolated examples).