1384252-72-5Relevant academic research and scientific papers
Molecular recognition of ketomalonates by asymmetric aldol reaction of aldehydes with secondary-amine organocatalysts
Kano, Taichi,Song, Sunhwa,Maruoka, Keiji
, p. 7037 - 7039 (2012/08/07)
A diastereo- and enantioselective aldol reaction between aldehydes and a synthetically useful ketomalonate 1c as a hydrated form was developed, and either anti- or syn-aldol adducts having a chiral tetrasubstituted carbon center were obtained in high enantioselectivities by use of a tetrazole analogue of l-proline (S)-2 or an axially chiral amino sulfonamide (S)-3 as catalyst. The Royal Society of Chemistry 2012.
