1384258-98-3Relevant academic research and scientific papers
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
Vendeville, Sandrine,Lin, Tse-I.,Hu, Lili,Tahri, Abdellah,McGowan, David,Cummings, Maxwell D.,Amssoms, Katie,Canard, Maxime,Last, Stefaan,Van Den Steen, Iris,Devogelaere, Benoit,Rouan, Marie-Claude,Vijgen, Leen,Berke, Jan Martin,Dehertogh, Pascale,Fransen, Els,Cleiren, Erna,Van Der Helm, Liesbet,Fanning, Gregory,Van Emelen, Kristof,Nyanguile, Origène,Simmen, Kenny,Raboisson, Pierre
, p. 4437 - 4443 (2012/07/17)
Optimization of a novel series of macrocyclic indole-based inhibitors of the HCV NS5b polymerase targeting the finger loop domain led to the discovery of lead compounds exhibiting improved potency in cellular assays and superior pharmacokinetic profile. F
