1384265-30-8

Basic information

• Product Name: Methyl 1-(4-BroMophenyl)-4-oxocyclohexanecarboxylate
• Synonyms: Methyl 1-(4-BroMophenyl)-4-oxocyclohexanecarboxylate
• CAS NO: 1384265-30-8
• Molecular Formula: C₁₄H₁₅BrO₃
• Molecular Weight: 311.1711
• Mol File: 1384265-30-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 1-(4-BroMophenyl)-4-oxocyclohexanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-(4-BroMophenyl)-4-oxocyclohexanecarboxylate(1384265-30-8)
• EPA Substance Registry System: Methyl 1-(4-BroMophenyl)-4-oxocyclohexanecarboxylate(1384265-30-8)

Safety Data

• Hazardous Substances Data: 1384265-30-8(Hazardous Substances Data)

Upstream product

• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1477524-28-9 methyl 2-(4-(4'-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477523-87-7 2-(4-(4′-(5-cyclobutyl-1,3,4-oxadiazol-2-ylamino)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetic acid 
• 1477524-33-6 methyl 2-(4-(4'-(2-methyl-5-(trifluoromethyl)oxazole-4-carboxamido)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477523-92-4 C₂₆H₂₄F₃N₃O₅ 
• 1477524-35-8 methyl 2-(4-(4'-(2-ethyl-4-methyloxazole-5-carboxamido)-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477523-93-5 2-(4-(4-(5-(2-ethyl-4-methyloxazole-5-carboxamido)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetic acid 
• 1477524-36-9 benzyl 2-(4-(4-(5-aminopyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477524-37-0 benzyl 2-(4-(4-(5-((5-(tert-butyl)oxazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477523-94-6 2-(4-(4-(5-((5-(tert-butyl)oxazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetic acid 
• 1477524-38-1 benzyl 2-(4-(4'-amino-[1,1'-biphenyl]-4-yl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 
• 1477524-05-2 (8-(4-bromophenyl)-1,4-dioxaspiro[4.5]decan-8-yl)methanol 
• 1477524-06-3 4-(4-bromophenyl)-4-(hydroxymethyl)cyclohexan-1-one 
• 1477524-07-4 methyl 2-(4-(4-bromophenyl)-4-(hydroxymethyl)cyclohexylidene)acetate 
• 1477524-08-5 methyl 2-(4-(4-bromophenyl)-2-oxabicyclo[2.2.2]octan-1-yl)acetate 

Relevant articles and documents

Successful strategies for mitigation of a preclinical signal for phototoxicity in a dgat1 inhibitor

Diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor Pradigastat (1) was shown to be effective at decreasing postprandial triglyceride levels in a patient population with familial chylomicronemia syndrome (FCS). Although pradigastat does not cause photosensitization in humans at the high clinical dose of 40 mg, a positive signal was observed in preclinical models of phototoxicity. Herein, we describe a preclinical phototoxicity mitigation strategy for diarylamine containing molecules utilizing the introduction of an amide or suitable heterocyclic function. This strategy led to the development of two second-generation compounds with low risk of phototoxicity, disparate exposure profiles, and comparable efficacy to 1 in a rodent lipid bolus model for post-prandial plasma triglycerides.