138429-50-2Relevant academic research and scientific papers
Nitriles in Heterocyclic Synthesis: New Routes to Polyfunctionally Substituted Pyridine, Pyridopyridine, Quinoline, and Pyridazine Derivatives
Elnadgi, Mohamed H.,Erian, Ayman W. W.
, p. 853 - 858 (2007/10/02)
The pyridine derivatives 4 and 10 are obtained by condensing β-aminocrotononitrile (1a) with malononitrile.Compound 4 affords the pyridylpyridazine 7 on coupling with aryldiazonium salts.The reaction of 1a with cyanothioacetamide affords 12 which affords the thienoyridine 13 on treatment with phenacylbromide, and pyridopyridine 15 on treatment with benzylidenemalononitrile (14).A variety of new pyridines, cyclohexadiene, and pyridopyridine derivatives were obtained from reaction of 2-amino-1-propene-1,1,3-tricarbonitrile (1b) and diethyl 3-amino-2-cyanopent-2-enedioate (1c) with Michael-systems.Reaction of 1b with acrylonitrile afforded an acyclic diadduct 25 which could be cyclized to the aminoquinoline 26.
