138429-71-7

Upstream product

• 138429-82-0 4-oxo-6-(pyridin-3-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 500-22-1 3-pyridinecarboxaldehyde 

Downstream Products

• 138429-83-1 2-benzylthio-4-chloro-6-(3-pyridyl)pyrimidine-5-carbonitrile 
• 138429-84-2 2-benzylthio-4-phenylamino-6-(3-pyridyl)pyrimidine-5-carbonitrile 
• 138540-29-1 2-Benzylsulfanyl-4-(2-hydroxy-1,1-dimethyl-ethylamino)-6-pyridin-3-yl-pyrimidine-5-carbonitrile 
• 138429-76-2 2-Benzylsulfanyl-4-(4-fluoro-phenylamino)-6-pyridin-3-yl-pyrimidine-5-carbonitrile 
• 138429-75-1 2-Benzylsulfanyl-4-(3-fluoro-phenylamino)-6-pyridin-3-yl-pyrimidine-5-carbonitrile 
• 138429-77-3 2-Benzylsulfanyl-4-(4-phenyl-piperazin-1-yl)-6-pyridin-3-yl-pyrimidine-5-carbonitrile 
• 138429-74-0 2-Benzylsulfanyl-4-pyridin-3-yl-6-(3-trifluoromethyl-phenylamino)-pyrimidine-5-carbonitrile 
• 138429-78-4 2-Benzylsulfanyl-4-[4-(3-hydroxy-propyl)-piperazin-1-yl]-6-pyridin-3-yl-pyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Synthesis and antifungal activity of some substituted pyrimidines

6-(3-Pyridyl)-2-thioxo-4-oxo-1H,3H-pyrimidine-5-carbonitrile 1 and their 6-(3-pyridyl)-2-substitutedthio-4-oxo-3H-pyrimidine-5-carbonitriles 2a-e and 2-substitutedthio-4-chloro-6-(3-pyridyl)-pyrimidine-5-carbonitriles 3a-e have been synthesized and tested for their antifungal activity against five human pathogenic fungi viz. A. fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton mentagrophytes and Sporothix schenckii. Out of the total screened compounds, compound 3a has shown promising antifungal activity against Aspergillus fumigatus, Trichophyton mentagrophytes and Cryptococcus neoformans with MIC values of 0.39, 0.19 and 1.56 μg/ml respectively. Compound 3b exhibited antifungal activity against Aspergillus fumigatus with the MIC value of 0.78 μg/ ml comparable to the standard drug ketoconazole.