1384306-65-3Relevant academic research and scientific papers
The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles
Migliorini, Antonella,Oliviero, Chiara,Gasperi, Tecla,Loreto, Maria Antonietta
, p. 4508 - 4521 (2012/07/27)
The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
