138433-00-8

Basic information

• Product Name: Benzenemethanol, 3,4,5-tris(dodecyloxy)-
• CAS NO: 138433-00-8
• Molecular Formula: C43H80O4
• Molecular Weight: 661.106
• Mol File: 138433-00-8.mol
• Article Data: 75

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3,4,5-tris(dodecyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,4,5-tris(dodecyloxy)-(138433-00-8)
• EPA Substance Registry System: Benzenemethanol, 3,4,5-tris(dodecyloxy)-(138433-00-8)

Safety Data

• Hazardous Substances Data: 138433-00-8(Hazardous Substances Data)

Upstream product

• 831-61-8 Ethyl gallate 
• 109-97-7 pyrrole 
• 117241-32-4 3,4,5-tris(dodecyloxy)benzaldehyde 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 121-79-9 Propyl gallate 
• 99-24-1 methyl galloate 
• 143-15-7 1-dodecylbromide 
• 112-29-8 1-bromo dodecane 
• 117241-31-3 3,4,5-tridodecyloxy benzoic acid 
• 1228276-91-2 propyl 3,4,5-tris(n-dodecan-1-yloxy)benzoate 
• 123126-39-6 methyl [3,4,5-tris(n-dodecan-1-yloxy)]benzoate 
• 117241-30-2 ethyl 3,4,5-tri(dodecyloxy)benzoate 

Downstream Products

• 1266383-06-5 3,4-bis(dodecyloxy)-5-[3,4,5-tris(dodecyloxy)benzyloxy]benzoic acid 
• 1245932-86-8 C₉₆H₁₆₄O₁₀ 
• 1372712-92-9 C₅₂H₈₆N₂O₄ 
• 1372713-03-5 Br^(1-)*C₅₆H₉₅N₂O₄⁽¹⁺⁾ 
• 1372713-04-6 Br^(1-)*C₅₇H₉₇N₂O₄⁽¹⁺⁾ 
• 253598-65-1 (3,4,5-tris-dodecyloxy-benzyl)-phosphonic acid diethyl ester 
• 1393356-54-1 5-[(4-{[3,4,5-tris(n-dodecyloxy)benzyl]oxy}naphthalen-1-yl)methylene]pyrimidine-2,4.6(1H,3H,5H)-trione 
• 212627-80-0 methyl 3,5-bis[3',4',5'-tris(n-dodecan-1-yloxy)benzyloxy]benzoate 

Relevant articles and documents

Highly luminescent liquid crystals by connecting 1,3,4-oxadiazole with thiazolo[5,4-d]thiazole units

The direct bonding between a thiazolo[5,4-d]thiazole and two 1,3,4-oxadiazole units allowed us to create a new and versatile rigid core for luminescent liquid crystal, which showed interesting and variable mesomorphic and photophysical properties. From the 5-bis(5-phenyl-1,3,4-oxadiazol-2-yl)thiazolo[5,4-d]thiazole new core, three molecules with different number of alkoxy chains were synthesized and had their properties correlated with the molecular structure. The molecule with two chains showed a smectic C mesophase, while the mesogens with four and six chains presented hexagonal columnar mesomorphism, which was confirmed by POM and XRD measurements. In addition, the molecule with six chains presented liquid crystalline behavior close to room temperature. In solution, the molecules presented strong photoluminescence ranging from blue to yellow, with quantum yields higher than 0.6. Excited state lifetimes allowed to correlate the fluorescence component associated to the different emitting species to the molecular organization in spin coated films. The molecular energy levels, together with thermal stability and possible charge carrier transport due to molecular packing, suggest that these molecules are promising for optoelectronic applications. Overall, this work contributes to the development of the use of thiazolo[5,4-d]thiazole in liquid crystals, demonstrating its great efficiency and versatility.

Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers

Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technology, have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers and glycodendrimers developed in our laboratory. Amphiphilic Janus dendrimers consist of functional hydrophilic dendrons conjugated to hydrophobic dendrons. Co-assembly of IAJDs with mRNA into dendrimersome nanoparticles (DNPs) occurs by simple injection in acetate buffer, rather than by microfluidic devices, and provides a very efficient system for delivery of mRNA to lung. Here we report the replacement of most of the hydrophilic fragment of the dendron from IAJDs, maintaining only its ionizable amine, while changing its interconnecting group to the hydrophobic dendron from amide to ester. The resulting IAJDs demonstrated that protonated ionizable amines play dual roles of hydrophilic fragment and binding ligand for mRNA, changing delivery from lung to spleen and/or liver. Replacing the interconnecting ester with the amide switched the delivery back to lung. Delivery predominantly to liver is favored by pairs of odd and even alkyl groups in the hydrophobic dendron. This simple structural change transformed the targeted delivery of mRNA mediated with IAJDs, from lung to liver and spleen, and expands the utility of DNPs from therapeutics to vaccines.

Controlling the Balance of Photoluminescence and Photothermal Effect in Cyanostilbene-Based Luminescent Liquid Crystals

Molecular motions of the luminescent liquid crystals (LLCs) show a significant effect on fluorescent emission and heat generation. In this article, a series of cyanostilbene-based LLCs (CSs: CS1-6, CS1-12, CS2-6 and CS2-12) are synthesized to investigate