1384338-79-7

Upstream product

• 1384338-77-5 3-((4-(1,3-dioxolan-2-yl)benzyl)amino)benzoic acid 
• 40681-88-7 4-(1,3-dioxolan-2-yl)benzaldehyde 
• 623-27-8 terephthalaldehyde, 

Downstream Products

• 1384338-81-1 (Z)-3-((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzoic acid 
• 1384338-83-3 (Z)-3-((4-((2,4-dioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzoic acid 
• 1384338-85-5 (R,Z)-dimethyl 2-(3-((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)-benzamido)pentanedioate 
• 1384338-89-9 (R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid 

Relevant academic research and scientific papers

Dual inhibitor of MurD and MurE ligases from escherichia coli and staphylococcus aureus

MurD and MurE ligases, consecutive enzymes participating in the intracellular steps of bacterial peptidoglycan biosynthesis, are important targets for antibacterial drug discovery. We have designed, synthesized, and evaluated the first d-glutamic acid-containing dual inhibitor of MurD and MurE ligases from Escherichia coli and Staphylococcus aureus (IC50 values between 6.4 and 180 μM) possessing antibacterial activity against Gram-positive S. aureus and its methicillin-resistant strain (MRSA) with minimal inhibitory concentration (MIC) values of 8 μg/mL. The inhibitor was also found to be noncytotoxic for human HepG2 cells at concentrations below 200 μM.