138442-65-6Relevant academic research and scientific papers
The Preparation and Reactions of Chiral Phosphorous Acid Diamides
Koeller, Kevin J.,Spilling, Christopher D.
, p. 6297 - 6300 (2007/10/02)
Chiral phosphorous acid diamides were prepared by condensation of N,N'-disubstituted C2 diamines with PCl3 followed by an equivalent of water.Deprotonation of these acids with n-butyl lithium or LDA gave the lithium salt which reacted smoothly with alkyl halides to give the substituted phosphonamides in good yield. Key Words: phosphorous acid; chiral; phosphonamide; alkylation; diamine.
