1384422-86-9Relevant academic research and scientific papers
Synthesis, DNA binding, hemolytic, and anti-cancer assays of curcumin I-based ligands and their ruthenium(III) complexes
Ali, Imran,Saleem, Kishwar,Wesselinova, Diana,Haque, Ashanul
, p. 1386 - 1398 (2013)
Knoevenagel condensates of curcumin I were synthesized with p-hydroxybenzaldehyde and 4-hydroxy-3,5-dimethoxy benzaldehyde and allowed to react with semicarbazide to form the corresponding curcumin I-based ligands. The ligands were complexed with ruthenium(III) metal ions. These complexes (C 1 and C2) were purified by chromatography and characterized as octahedral geometries by analytical techniques. The binding affinities of these compounds for calf thymus DNA were determined. DNA binding constants (K b ) for the two complexes were 1.46 × 10 4 and 3.54 × 104 M-1, respectively. Similarly, the binding constants (K sv) for C1 and C 2 were 9.40 × 103 and 9.30 × 103 M-1, respectively. Hemolytic assays of the compounds showed less toxicity than the standard anti-cancer drug letrazole. The compounds showed good activity against the cervical cancer cell line (HeLa) and moderate activity against liver hepatocellular carcinoma (HepG2), breast cancer (MDA-MB-231) and human colon adenocarcinoma (HT-29) cells lines. These compounds showed potential for treatment of cervical cancer in the future.
