1384477-99-9Relevant academic research and scientific papers
Highly selective base-catalyzed ring closing Ugi-adducts from the reaction of 2-formylindole, 2-bromoacetic acid, amines and isocyanides
Shiri, Morteza,Bozorgpour-Savadjani, Zahra
, p. 389 - 396 (2015/02/05)
The intermediate products of the Ugi reaction between indole-2-carboxaldehyde, 2-bromoacetic acid, amines and isocyanides were treated with Cs2CO3 in DMF to form a series of novel cyclized 1,2-dihydropyrazino[1,2-a]indol-3(4H)-ones (indole -NH cyclization) as major and piperazin-2-ones (amide -NH cyclization) as minor products.
A novel intramolecular Ugi 3CC for the synthesis of N-alkyl-3-oxo-2-aryl-1, 2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamides
Subba Reddy,Dey, Sujit Kumar,Yadav,Sridhar
, p. 3676 - 3679 (2012/09/21)
An intramolecular Ugi reaction of 2-(2-formyl-1H-indol-1-yl)acetic acid with aryl amines and isocyanides has been developed to produce a novel class of N-alkyl-3-oxo-2-aryl-1,2,3,4-tetrahydropyrazino[1,2-a]indole-1-carboxamides in good yields. This is the
