1384524-22-4Relevant academic research and scientific papers
Synthesis of a new chiral sulfonic acid
Das, Joydeb,Le Cavelier, Fabien,Rouden, Jacques,Blanchet, Jermoe
, p. 1349 - 1352 (2012)
A convenient route to an original chiral sulfonic acid is disclosed. The synthesis is based on an optimized and regioselective direct bis-orthoarylation of a commercially available phenol, followed by a Newman-Kwart rearrangement. Resolution by preparative chiral HPLC and oxidative cleavage give the targeted Brnsted acid in >99% ee. Georg Thieme Verlag Stuttgart · New York.
