138457-95-1Relevant articles and documents
Asymmetric Synthesis via Heterocyclic Intermediates, XLVII. Asymmetric Synthesis of (+)-(1R,2S)-allo-Coronamic Acid
Groth, Ulrich,Halfbrodt, Wolfgang,Schoellkopf, Ulrich
, p. 351 - 356 (2007/10/02)
allo-Coronamic acid (1) was synthesized in five steps enantiomerically and diastereomerically virtually pure by starting from the bislactim ethers of cyclo(-L-Val-Gly-) (3a) or cyclo(-L-tert-Leu-Gly-) (3b) in an overall yield of 31percent.The key step of this synthesis is the intramolecular alkylation of the lithium azaenolate derived from the allylic chloride 4. Key Words: Amino acids / Cyclopropanes / Cyclopropanation, diastereoselective / Bislactim ether method
SYNTHESIS OF 1-AZIDOCYCLOPROPANECARBOXYLATES FROM 2-AZIDO-2-ALKENOATES
Hiyama, Tamejiro,Kai, Mariko
, p. 2103 - 2104 (2007/10/02)
Addition of diazomethane to 2-azido-2-alkenoates followed by pyrolysis of the resulting pyrazoline derivatives affords the title compounds.