1384570-83-5

Basic information

• Product Name: 5'-O-dimetoxytrityl-2-selenouridine
• Synonyms: 5'-O-dimetoxytrityl-2-selenouridine
• CAS NO: 1384570-83-5
• Molecular Weight: 609.537
• Mol File: 1384570-83-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-dimetoxytrityl-2-selenouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimetoxytrityl-2-selenouridine(1384570-83-5)
• EPA Substance Registry System: 5'-O-dimetoxytrityl-2-selenouridine(1384570-83-5)

Safety Data

• Hazardous Substances Data: 1384570-83-5(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 7782-49-2 selenium 
• 1627601-87-9 5'-O-dimethoxytrityl-S-geranyl-2-thiouridine 
• 163496-06-8 5’-O-dimetoxytrityl-2-thiouridine 
• 20235-78-3 2-thiouridine 
• 1401688-09-2 S-geranyl-2-thiouridine 
• 1384570-81-3 C₃₁H₃₂N₂O₇S 

Downstream Products

• 1384570-93-7 C₃₉H₄₇N₃O₇SeSi 
• 1384570-90-4 C₃₉H₄₇N₃O₇SeSi 
• 1384570-85-7 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine 
• 1384570-88-0 C₃₆H₄₄N₂O₇SeSi 
• 1262964-71-5 C₄₈H₆₄N₅O₈PSeSi 

Relevant articles and documents

Transformation of a wobble 2-thiouridine to 2-selenouridine via S-geranyl-2-thiouridine as a possible cellular pathway

The newly discovered S-geranylated 2-thiouridines (geS2U) (Dumelin et al., 2012) and 2-selenouridines (Se2U) were recently shown to be synthesized by a single enzyme (selenouridine synthase, SelU) through two distinct pathways using the same 2-thiouridine substrate (S2U); however, no clear catalytic mechanism was proposed. We suggest that S-geranyl-2-thiouridine is an intermediate of the SelU-catalyzed conversion of S2U to Se2U. The successful chemical transformation of S2U → geS2U → Se2U is demonstrated here as an initial approximation of the intracellular pathway. The structure of Se2U was confirmed by spectroscopic methods, which included, for the first time, 77Se NMR data (δ 354 ppm).2014 Elsevier Inc. All rights reserved.