1384724-89-3Relevant academic research and scientific papers
Selective synthesis of seven- and eight-membered ring sultams via two tandem reaction protocols from one starting material
Wang, Min,Wang, Yanjie,Qi, Xueyong,Xia, Guohua,Tong, Kun,Tu, Jinchang,Pittman, Charles U.,Zhou, Aihua
, p. 3700 - 3703 (2012/08/28)
From one starting material, two tandem reaction protocols to synthesize seven- and eight-membered ring sultams were developed. One protocol employs intermolecular epoxide ring-opening by NaN3, followed by an intramolecular 7-endo-trig oxa-Michael addition reaction. The second protocol applies to intermolecular aza-Michael addition of a primary amine, followed by 8-endo-tet intramolecular epoxide ring-opening of the resultant amine intermediate. Both protocols afforded the respective sultams in good yields under mild reaction conditions.
