1384736-07-5 Usage
Uses
Used in Pharmaceutical Research:
(3β)-24-BroMo-3-[(tert-butyl)diMethylsilyloxy]-chol-5-ene is used as a reactant for the preparation of cholesterol side-chain analogs in the pharmaceutical industry. These analogs are crucial for understanding the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes, which play a significant role in the pathogenesis of tuberculosis. The study of these enzymes and their interactions with cholesterol analogs can lead to the development of novel therapeutic strategies against tuberculosis.
Used in Chemical Synthesis:
In the field of chemical synthesis, (3β)-24-BroMo-3-[(tert-butyl)diMethylsilyloxy]-chol-5-ene serves as a key intermediate for the synthesis of various complex organic molecules. Its unique structure and functional groups make it a valuable building block for the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Material Science:
(3β)-24-BroMo-3-[(tert-butyl)diMethylsilyloxy]-chol-5-ene can also be utilized in the field of material science for the development of novel materials with specific properties. Its unique chemical structure and functional groups can be exploited to create materials with tailored characteristics, such as improved thermal stability, enhanced mechanical properties, or specific interactions with other molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1384736-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,4,7,3 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1384736-07:
(9*1)+(8*3)+(7*8)+(6*4)+(5*7)+(4*3)+(3*6)+(2*0)+(1*7)=185
185 % 10 = 5
So 1384736-07-5 is a valid CAS Registry Number.
1384736-07-5Relevant academic research and scientific papers
Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1
Johnston, Jonathan B.,Singh, Arti A.,Clary, Anaelle A.,Chen, Chiung-Kuan,Hayes, Patricia Y.,Chow, Sharon,De Voss, James J.,Ortiz De Montellano, Paul R.
experimental part, p. 4064 - 4081 (2012/09/22)
We report the synthesis and evaluation of a series of cholesterol side-chain analogs as mechanistic probes of three important Mycobacterium tuberculosis cytochrome P450 enzymes that selectively oxidize the ω-position of the methyl-branched cholesterol side-chain. To probe the structural requirements for the thermodynamically disfavored ω-regiospecificity we compared the binding of these substrate analogs to each P450, determined the turnover rates, and characterized the enzymatic products. The results are discussed in the context of the structure-activity relationships of the enzymes and how their active sites enforce ω-oxidation.
