138479-47-7

Usage

Uses

Used in the Food Industry:
Benzaldehyde, 2-(1H-pyrazol-1-yl)is used as a flavoring agent for its strong almond-like aroma, enhancing the taste and aroma of various food products.
Used in the Pharmaceutical Industry:
Benzaldehyde, 2-(1H-pyrazol-1-yl)serves as a precursor in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in the Agrochemical Industry:
As a precursor in the synthesis of agrochemicals, Benzaldehyde, 2-(1H-pyrazol-1-yl)plays a role in the development of pesticides and other agricultural chemicals to protect crops and enhance yield.
Used in Antifungal and Antimicrobial Applications:
Benzaldehyde, 2-(1H-pyrazol-1-yl)has been studied for its potential use as an antifungal and antimicrobial agent due to its inhibitory effects on certain microorganisms, offering a possible alternative for controlling microbial growth in various settings.

InChI:InChI=1/C10H8N2O/c13-8-9-4-1-2-5-10(9)12-7-3-6-11-12/h1-8H

Upstream product

• 288-13-1 NH-pyrazole 
• 446-52-6 2-Fluorobenzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1126-00-7 1-phenylpyrazole 
• 741717-59-9 (2-(1H-pyrazol-1-yl)phenyl)methanol 

Downstream Products

• 1020045-42-4 α-phenyl-(2-(1H-pyrazol-1-yl))benzyl alcohol 
• 1033804-95-3 4-chloro-6-[2,2,2-trifluoro-1-(2-pyrazol-1-yl-phenyl)ethoxy]pyrimidine 
• 1033804-94-2 2,2,2-trifluoro-1-(2-pyrazol-1-yl-phenyl)ethanol 

Relevant academic research and scientific papers

Mildness in preparative conditions directly affects the otherwise straightforward syntheses outcome of Schiff-base isoniazid derivatives: Aroylhydrazones and their solvolysis-related dihydrazones

Aroylhydrazones are versatile compounds with a series of applications, from biological to technological spheres. The simplicity of their preparation allows for a great chemical variability and synthetic manageability. However, the process can be not as st

Catalytic, Directed C-C Bond Functionalization of Styrenes

A method for catalytic conversion of C(aryl)-C(alkenyl) bonds in styrene derivatives to new C-C bonds is developed. In the presence of a rhodium catalyst, the alkenyl groups of styrenes bearing a pyrazolyl directing group were efficiently converted to other carbon substituents upon reacting with various alkenes including styrenes, aliphatic alkenes, and allyl alcohols. It is also indicated that the C-C bond cleavage proceeded via a hydrometalation/β-carbon elimination pathway.

Aromatic C-H Methylation and Other Functionalizations via the Rh(III)-Catalyzed Migratory Insertion of Bis(phenylsulfonyl)carbene and Subsequent Transformations

The Rh(III)-catalyzed migratory insertion of bis(phenylsulfonyl)carbene into aromatic C-H bonds has been developed. A variety of bis(phenylsulfonyl)methyl derivatives were prepared with good yields under mild conditions. The methylated products were readily obtained after reductive desulfonylation. Furthermore, the diverse transformations of bis(phenylsulfonyl)methyl to trideuteriomethyl, aldehyde, and other functional groups were demonstrated.

Cobalt(III)-Catalyzed Direct ortho-Alkenylation of Arylpyrazoles: A Comparative Study on Decarboxylation and Desilylation

A comparative study on CoIII-catalyzed direct C–H bond alkenylation of 1-phenylpyrazole derivatives with alkynyl carboxylic acids and arylalkynylsilanes under redox-neutral conditions has been disclosed. These methods show excellent selectivity with good to excellent yields. Trimethylsilylacetylene has been utilized as a vinyl source to obtain the corresponding styrene derivatives. The major differences between these two reactions are the decarboxylation proceeds in the presence of a base additive whereas the desilylation takes place in the presence of an acid additive. The developed methodologies are compatible with a variety of functional groups.

CXCR4 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Extrusion of CO from aryl ketones: Rhodium(I)-catalyzed C-C bond cleavage directed by a pyridine group

Snipping tool: The rhodium(I)-catalyzed extrusion of carbon monoxide from biaryl ketones and alkyl/alkenyl aryl ketones was developed to produce biaryls and alkyl/alkenyl arenes, respectively, in high yields (see scheme). A wide range of functionalities are tolerated. Not only does this method provide an alternative pathway to construct useful scaffolds, but also offers a new strategy for C-C bond activation. Copyright

Pyridinyl directed alkenylation with olefins via Rh(III)-catalyzed C-C bond cleavage of secondary arylmethanols

Novel C-C bond cleavage of secondary alcohols through Rh(III)-catalyzed β-carbon elimination directed by a pyridinyl group is reported. A five-membered rhodacycle is proposed as a key intermediate, which undergoes further alkenylation with various olefins. This novel transformation shows high efficiency along with excellent selectivity in mild conditions. A wide range of functionalities are compatible. This study offers a new strategy to carry out C-C bond activation.

Cyclization Reactions in Azole Chemistry: The Reaction of Some Azoles with o-Fluoroacetophenone, o-Fluorobenzaldehyde and o-Fluorobenzophenone

The reactions of some azoles with o-fluoro-acetophenone, -benzaldehyde and -benzophenone in dimethyl sulfoxide solution in the presence of anhydrous potassium carbonate have been investigated.In addition to the expected substitution products, cyclization