1384847-63-5Relevant academic research and scientific papers
Total syntheses of cladoacetals A and B: Confirmation of absolute configurations
Hsu, Day-Shin,Lin, Shih-Chung
experimental part, p. 6139 - 6146 (2012/10/08)
The first enantioselective syntheses of cladoacetals A (1a, overall yield: 16%) and B (1b, overall yield: 34%) from crotonaldehyde in nine and seven steps, respectively, have been accomplished. Sharpless asymmetric dihydroxylation, Suzuki coupling, and acid-catalyzed intramolecular acetalization were the key steps in the syntheses. The absolute configuration of natural (+)-cladoacetal A was affirmed to be 1S,3S,4R, whereas that of (-)-cladoacetal B was affirmed to be 1R,3S,4S.
