13849-90-6 Usage
Description
3-Oxopomolic acid, a ketocarboxylic acid derivative of the naturally occurring pomolic acid, is a chemical compound found in fruits of several species within the Rosaceae family. It is a yellow crystalline solid that is sparingly soluble in water and relatively stable under normal conditions. Its unique chemical structure and properties make it a valuable compound in organic chemistry research and drug development.
Uses
Used in Pharmaceutical Synthesis:
3-Oxopomolic acid is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
Due to its distinctive properties, 3-Oxopomolic acid is utilized in organic chemistry research to explore its potential applications and reactions with other compounds. This research can lead to the discovery of new chemical reactions and the development of novel organic compounds.
Used in Drug Development:
3-Oxopomolic acid's stability and solubility characteristics make it a promising candidate for drug development. Its potential use as an intermediate in the synthesis of pharmaceuticals can contribute to the creation of new and effective treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 13849-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,4 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 13849-90:
(7*1)+(6*3)+(5*8)+(4*4)+(3*9)+(2*9)+(1*0)=126
126 % 10 = 6
So 13849-90-6 is a valid CAS Registry Number.
13849-90-6Relevant articles and documents
Pentacylic triterpenes from Lavandula coronopifolia: structure related inhibitory activity on α-glucosidase
Elsbaey, Marwa,Mwakalukwa, Rogers,Shimizu, Kuniyoshi,Miyamoto, Tomofumi
, p. 1436 - 1444 (2019/08/26)
Ten pentacyclic triterpenes (1-10) were isolated from Lavandula coronopifolia. We evaluated their α-glucosidase inhibitory activity, and found that the aglycones, 1, 2, 3, 4, 7 and 10 showed superior IC50 values to the positive control. In order to explain the structural requirements for α-glucosidase inhibitory activity, eleven derivatives were prepared, including one new compound, 2-formyl-(A)1–19α-hydroxy-1-norursane-2, 12-dien-28-oic acid 10c. The results demonstrated that a free hydroxyl at ring-A and a free carboxylic group at position 28 are key structural features for the α-glucosidase inhibitory activity, also that an ursane skeleton is optimum for the activity. Additionally, enzyme kinetic analysis of pomolic acid 2, the most potent compound, revealed that it inhibited α-glucosidase in a mixed-type manner. The molecular docking simulation validated this type of inhibition and highlighted the role of the C-3 hydroxyl and C-28 carboxylic groups in interaction with the enzyme in silico.