138494-29-8

Upstream product

• 138494-30-1 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine 

Downstream Products

• 138603-20-0 N-(1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-chloro-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-4-methoxy-benzamide 
• 138494-34-5 Succinic acid mono-{(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-chloro-ethoxy)-ethoxy]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester 
• 138603-22-2 3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁴-anisoylcytidine 

Relevant academic research and scientific papers

SOLID PHASE SYNTHESIS OF OLIGORIBONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH USING 2'-O-1-(2-CHLOROETHOXY)ETHYL PROTECTION

The new type protecting group, 1-(2-chloroethoxy)ethyl (Cee) group has been employed for the protection of the 2'-OH groups of ribonucleoside residues in the synthesis of oligoribonucleotides by the phosphoramidite approach on a solid support, using the acid-labile 5'-O-dimethoxytrityl (DMTr) group.This group is completely stable under the acidic conditions required to remove the 5'-terminal protecting groups in oligonucleotide synthesis on a solid support, and yet is easily removable under mild condition of acidic hydrolysis (pH 2.0) for the final unblocking step.The Cee-protected ribonucleoside 3'-phosphoramidite units were evaluated in the synthesis of a series of oligoribonucleotides consisting of the homopolymers of cytidine, the box 9R and 9R' sequences of Tetrahymena rRNA, and a leader sequence of phage Qβ-A protein mRNA.A full data for the deprotection and purification of synthetic oligoribonucleotides are also described.