138494-49-2Relevant academic research and scientific papers
Preparation of New Nitrogen-Bridged Heterocycles. 27. First Synthesis of 1,3-Thiazinoindolizine Derivatives
Kakehi, Akikazu,Ito, Suketaka,Sakurai, Tosio,Urushido, Kunio,Isawa, Hidetoshi,Enomoto, Manabu
, p. 3289 - 3295 (2007/10/02)
Potassium 2-indolizinethiolates, generated in situ from the treatment of dialkyl 2-indolizine-1,3-dicarboxylates with potassium t-butoxide in N,N-dimethylformamide, reacted smoothly with various isothiocyanates and isocyanates with the elimination of alkoxide ions to give new heterocyclic compounds, alkyl 4(3H)-oxo-2-thioxo- and 2,4(3H)-dioxo-2H-1,3-thiazinoindolizine-10-carboxylates, in moderate to good yields.The structures of these 1,3-thiazinoindolizine derivatives were determined mainly by elemental analyses and spectral inspections, and the structural assignment was finally confirmed by the single crystal X-ray analyses of two compounds.
