1384952-83-3Relevant academic research and scientific papers
Microwave-assisted synthesis of novel bis-flavone dimers as new anticancer agents
McGown, Andrew,Ragazzon-Smith, Abby,Hadfield, John A.,Potgetier, Herman,Ragazzon, Patricia A.
, p. 66 - 75 (2019/05/04)
In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.
