1385015-44-0Relevant articles and documents
Synthesis of new 4-aryl-1-(biarylmethylene)piperidines. Structural analogs of adoprazine (SLV313)
Ullah, Nisar,Al-Shaheri, Ali Ahmed Qaid
, p. 253 - 262 (2012)
A series of new 4-aryl-1-(biarylmethylene)piperidines have been synthesized. They are structurally related to SLV-313, a potential atypical antipsychotic agent with potent D2 receptor antagonist and 5-HT 1A receptor agonist properties. Suzuki-Miyaura reaction of cyclic vinyl boronates, derived from the vinyl triflates of N-protected tetrahydropyridines, with appropriate aryl halides yielded 4-arylpiperidines. The reductive amination of the latter with suitable biarylaldehdyes accomplished the synthesis of the new compounds.
4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS
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Paragraph 0034, (2014/10/16)
The 4-aryl-1-(biarylmethylene)piperidine compounds are piperadine compounds having a biaryl substituent linked to the nitrogen atom of the piperidine ring by a methylene (—CH2—) group, and an aryl moiety attached to the 4-position of the piperi