1385015-62-2

Upstream product

• 680203-54-7 3-cyclopenten-1-yl-benzaldehyde 
• 1385015-41-7 C₂HF₃O₂*C₁₄H₁₆N₂O 
• 1374876-29-5 2-(benzyloxy)-8-bromoquinoline 
• 1385015-46-2 tert-butyl 4-(2-(benzyloxy)quinolin-8-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1385015-48-4 tert-butyl 4-(2-oxo-1,2-dihydroquinolin-8-yl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS

The 4-aryl-1-(biarylmethylene)piperidine compounds are piperadine compounds having a biaryl substituent linked to the nitrogen atom of the piperidine ring by a methylene (—CH2—) group, and an aryl moiety attached to the 4-position of the piperi

Synthesis of new 4-aryl-1-(biarylmethylene)piperidines. Structural analogs of adoprazine (SLV313)

A series of new 4-aryl-1-(biarylmethylene)piperidines have been synthesized. They are structurally related to SLV-313, a potential atypical antipsychotic agent with potent D2 receptor antagonist and 5-HT 1A receptor agonist properties. Suzuki-Miyaura reaction of cyclic vinyl boronates, derived from the vinyl triflates of N-protected tetrahydropyridines, with appropriate aryl halides yielded 4-arylpiperidines. The reductive amination of the latter with suitable biarylaldehdyes accomplished the synthesis of the new compounds.