1385017-91-3

Upstream product

• 1385017-77-5 C₁₂H₁₁NO₃ 
• 108-24-7 acetic anhydride 

Downstream Products

• 1385018-09-6 (E)-2-methyl-5-(4-nitrobenzylidene)-4-oxocyclopent-1-en-1-yl acetate 
• 1385018-27-8 (Z)-2-methyl-5-(4-nitrobenzylidene)-4-oxocyclopent-1-en-1-yl acetate 

Relevant academic research and scientific papers

Diastereoselective [4 + 1] Cycloaddition of Alkenyl Propargyl Acetates with CO Catalyzed by [RhCl(CO)2]2

A class of alkenyl propargyl acetates, RCH(OAc)C≡CC(CH 3)=CH2 (5), are found to undergo [4 + 1] cycloaddition with CO (1 atm) in the presence of [RhCl(CO)2]2 in refluxing 1,2-dichloroethane to give cyclopentenones (6) in good yields. It has been demonstrated that, when the R group of 5 is a phenyl group bearing o-electron-withdrawing substituents, up to 10:1 diastereoselectivity and 96% yield can be achieved for the [4 + 1] cycloaddition. This process provides a convenient method to construct highly functionalized cyclopentenones that are useful in organic synthesis.