1385018-58-5

Basic information

• Product Name: AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]-
• Synonyms: AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]-;N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]- AcetaMide;AgoMelatine DiMer AcetaMide;The dimer agomelatine 2
• CAS NO: 1385018-58-5
• Molecular Formula: C28H29NO3
• Molecular Weight: 427.53476
• Product Categories: Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1385018-58-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.156±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]-(1385018-58-5)
• EPA Substance Registry System: AcetaMide, N,N-bis[2-(7-Methoxy-1-naphthalenyl)ethyl]-(1385018-58-5)

Safety Data

• Hazardous Substances Data: 1385018-58-5(Hazardous Substances Data)

Usage

Uses

N,N-Agomelatine Dimer is an impurity of Agomelatine (A430020).

Upstream product

• 108-24-7 acetic anhydride 
• 138113-08-3 (7-methoxy-1-naphthyl)acetonitrile 

Relevant articles and documents

A method of preparing agomelatine acetylmethylene diamine

The invention discloses a method for preparing agomelatine acetyl diamine. The method comprises the following steps: heating and enabling a solvent, an anhydrous raney nickel catalyst, (7-methoxy-1-naphthyl) acetonitrile and acetic anhydride to react with one another in the presence of hydrogen, then carrying out reduced pressure concentration, washing with hydrochloric acid and staturated sodium chloride, then crystallizing by using ethyl acetate, separating out agomelatine acetyl diamine, and drying agomelatine acetyl diamine to obtain a finished product. The method can be used for preparing the process impurity of agomelatine, namely the agomelatine acetyl diamine, the operation method is simple and easily available; agomelatine is high in yield and high in purity; an excellent preparation method is provided for batch production of agomelatine acetyl diamine.