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1385032-72-3

C26H29ClN4O4 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1385032-72-3 Structure

  • Basic information

    1. Product Name: C26H29ClN4O4
    2. Synonyms:
    3. CAS NO:1385032-72-3
    4. Molecular Formula:
    5. Molecular Weight: 496.994
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1385032-72-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C26H29ClN4O4(CAS DataBase Reference)
    10. NIST Chemistry Reference: C26H29ClN4O4(1385032-72-3)
    11. EPA Substance Registry System: C26H29ClN4O4(1385032-72-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1385032-72-3(Hazardous Substances Data)

1385032-72-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1385032-72-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,5,0,3 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1385032-72:
(9*1)+(8*3)+(7*8)+(6*5)+(5*0)+(4*3)+(3*2)+(2*7)+(1*2)=153
153 % 10 = 3
So 1385032-72-3 is a valid CAS Registry Number.

1385032-72-3Upstream product

1385032-72-3Relevant articles and documents

A new class of highly potent and selective endomorphin-1 analogues containing α-methylene-β-aminopropanoic acids (map)

Wang, Yuan,Xing, Yanhong,Liu, Xin,Ji, Hong,Kai, Ming,Chen, Zongyao,Yu, Jing,Zhao, Depeng,Ren, Hui,Wang, Rui

, p. 6224 - 6236 (2012)

A new class of endomorphin-1 (EM-1) analogues were synthesized by introduction of novel unnatural α-methylene-β-amino acids (Map) at position 3 or/and position 4. Their binding and functional activity, metabolic stability, and antinociceptive activity were determined and compared. Most of these analogues showed high affinities for the μ-opioid receptor and an increased stability in mouse brain homogenates compared with EM-1. Examination of cAMP accumulation and ERK1/2 phosphorylation in HEK293 cells confirmed the agonist properties of these analogues. Among these new analogues, H-Tyr-Pro-Trp-(2-furyl)Map-NH2 (analogue 12) exhibited the highest binding potency (Kiμ = 0.221 nM) and efficacy (EC 50 = 0.0334 nM, Emax = 97.14%). This analogue also displayed enhanced antinociceptive activity in vivo in comparison to EM-1. Molecular modeling approaches were then carried out to demonstrate the interaction pattern of these analogues with the opioid receptors. We found that, compared to EM-1, the incorporation of our synthesized Map at position 4 would bring the analogue to a closer binding mode with the μ-opioid receptor.

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