138504-31-1

Basic information

• Product Name: 4-FLUORO-2'-IODOBENZOPHENONE
• Synonyms: 4-FLUORO-2'-IODOBENZOPHENONE;UKRORGSYN-BB BBV-5117248
• CAS NO: 138504-31-1
• Molecular Formula: C13H8FIO
• Molecular Weight: 326.1
• Mol File: 138504-31-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 396.6°C at 760 mmHg
• Flash Point: 193.6°C
• Appearance: /
• Density: 1.682g/cm³
• Vapor Pressure: 1.69E-06mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 4-FLUORO-2'-IODOBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2'-IODOBENZOPHENONE(138504-31-1)
• EPA Substance Registry System: 4-FLUORO-2'-IODOBENZOPHENONE(138504-31-1)

Safety Data

• Hazardous Substances Data: 138504-31-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8FIO/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8H

Upstream product

• 88-67-5 2-Iodobenzoic acid 

Relevant articles and documents

Novel transformation of aryl 2-iodophenyl ketones into 1,3-diarylisoquinolines with (TMS)2NH, styrenes, NIS, and tBuOK

Treatment of aryl 2-iodophenyl ketones with TMS2NH in the presence of Sc(OTf)3 at warming conditions, followed by the reaction with styrenes and NIS gave N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines. Further treatment of N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines with tBuOK in the presence of 1,10-phenanthroline at 120 °C generated 1,3-diarylisoquinolines in moderate yields through SET from tBuOK onto the iodophenyl group to form aryl radicals, their 6-endo-trig cyclization onto the vinyl groups, and aromatization of the cyclized intermediates. The present method is a novel approach for the preparation of the isoquinoline core via two steps from aryl 2-iodophenyl ketones.