1385079-00-4Relevant academic research and scientific papers
Advances in proline ligation
Townsend, Steven D.,Tan, Zhongping,Dong, Suwei,Shang, Shiying,Brailsford, John A.,Danishefsky, Samuel J.
, p. 3912 - 3916 (2012/05/04)
Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.
