138508-10-8

Upstream product

• 109-01-3 1-methyl-piperazine 
• 151072-00-3 (2S,4S)-5-p-nitrobenzyloxycarbonyl-2-thia-5-azabicyclo<2.2.1>heptan-3-one 

Downstream Products

• 138458-35-2 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-3-[(3S,5S)-5-(4-methyl-piperazine-1-carbonyl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

An Efficient Synthesis of (2S,4S)-2-Substituted-4-mercaptopyrrolidine Derivatives

An efficient synthesis of (2S,4S)-2-substituted 4-mercapto-1-p-nitrobenzyloxycarbonylpyrrolidine (2) was studied.Intramolecular cyclization of (2S,4R)-1-p-nitrobenzyloxycarbonyl-4-methanesulfonyloxy-2-pyrrolidinethiocarboxylic acid (8), derived from trans-4-hydroxy-L-proline (3), afforded (1S,4S)-5-p-nitrobenzyloxycarbonyl-2-thia-5-azabicycloheptan-3-one (7).Reaction of 7 with primary amine, secondary amine and alkoxide afforded corresponding 2 in high yield.

Pyrrolidine derivatives and process for preparing the same

Pyrrolidine derivatives of the formula (1): STR1 wherein R is a protective group of the amino group, intermediates for constructing the 2-positioned side chain of antibacterial penem and carbapenem compounds, are prepared by allowing STR2 to react with ac