138509-35-0Relevant academic research and scientific papers
PHENYL-SUBSTITUTED CYCLOALKENYL COMPOUNDS USEFUL AS PDE IV INHIBITORS
-
, (2008/06/13)
A compound of formula (I) or a pharmaceutically acceptable salt thereof: STR1 wherein: R 1 is--CH 3 or--CH 2 CH. sub.3 unsubstituted or substituted by 1 to 3 fluorines; X is O or S(O) s where s=0 to 2;R 2 is C 4-C 6 cyclic alkyl, optionally substituted by one to three methyl groups or one ethyl group;--CH 2-cyclopentyl,--CH 2-cyclopropyl, 3-tetrahydrofuranyl, C 1-7 alkyl, CH 3 or CH 2 CH 3 substituted by one to three fluorines;--(CH. sub.2) n COO(CH 2) g CH. sub.3, or (CH 2) n O(CH 2) g CH. sub.3, wherein n is 2 to 4 and g is 0 to 2; R 3 represents a moiety of formula (a); STR2 wherein R 4 and R 5 each represent hydrogen or R 4 and R 5 together represent a bond; B represents > C=O, > C=S or > CH--R. sub.6 wherein R 6 represents H, OH, C 1-6 alkoxy or C. sub.1-6 thioalkoxy; and m and r each independently represents zero or an integer in the range of 1 to 4 wherein m+r represents an integer in the range of from 2 to 4; with the proviso that when R 1 is methyl, X is oxygen, R. sub.2 is methyl or cyclopenyl, R 3 does not represent cyclopent-1,2-ene-3-one.
