138535-00-9Relevant articles and documents
Selective One-Pot Three-Step Cascade Reaction: From Aromatic Aldehydes to 2,2-Diphenylethanol Derivatives
Billamboz, Muriel,Imbs, Claire,Banaszak-Léonard, Estelle,Len, Christophe
supporting information, p. 835 - 843 (2017/06/23)
We report herein a green and scalable one-pot, three-step, pinacol-coupling-rearrangement-reduction cascade reaction useful for the formation of 2,2-diphenylethanol derivatives. The reaction is carried out in water in the presence of a commercially available and regenerable supported acid under moderate pressure. A dozen of aromatic aldehydes have been successfully submitted to the standard protocol giving the target 2,2-diarylethanol derivatives in good yield (70-85%).