138557-92-3

Upstream product

• 588-63-6 3-phenoxypropyl bromide 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 685872-99-5 4-[4-(3-bromopropoxy)benzenesulfonyl]morpholine 
• 138557-93-4 4-(3-bromopropoxy)-N-methylbenzenesulfonamide 
• 1375454-15-1 1-benzhydryl-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375454-14-0 1-[4-(N,N-dimethylamino)phenyl]-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375454-13-9 1-(1-naphthyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375454-12-8 1-(4-methylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375454-11-7 1-(4-acetylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-98-7 1-phenyl-3-[4-(3-(4-ethoxycarbonylpiperidin-1-yl)propoxy)benzene]sulfonylurea 
• 1375453-97-6 1-(4-trifluoromethylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-96-5 1-(2,5-dichlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-95-4 1-cyclohexyl-3-[4-(3-piperidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-94-3 1-phenyl-3-[4-(3-piperidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-93-2 1-isopropyl-3-[4-(3-piperidin-1-ylpropoxy)benzene]sulfonylurea 
• 1375453-92-1 1-(4-trifluoromethylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)benzene]sulfonylurea 

Relevant academic research and scientific papers

NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF

The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies

The combination of antagonism at histamine H3 receptor and the stimulation of insulin secretion have been proposed as an approach to new dual therapeutic agents for the treatment of type 2 diabetes mellitus associated with obesity. We have desi

ARYLOXYALKYLAMINE DERIVATES AS H3 RECEPTOR LIGANDS

The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Keratinocyte growth inhibitors and hydroxamic acid derivatives

This invention relates to a keratinocyte-proliferation inhibitor comprising as active ingredient a compound having an activity of inhibiting the solubilization of heparin-binding EGF-like growth factor bound to cell membranes and a compound of the formula (I); or pharmaceutically acceptable salt thereof, wherein R1, R2, R3 are hydrogen atom or alkyl and X is substituted benzene or the like.

Pyrimidinedione derivatives and antiarrhythmic agents containing same

Pyrimidinedione derivatives of the formula: STR1 wherein R1 and R2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R3, R4, X1, X2 and X3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.