138564-69-9Relevant academic research and scientific papers
Novel antidiabetic and hypolipidemic agents. 5. Hydroxyl versus benzyloxy containing chroman derivatives
Reddy, K. Anji,Lohray,Bhushan,Reddy, A. Sekar,Mamidi, N. V. S. Rao,Reddy, P. Papi,Saibaba,Reddy, N. Jaipal,Suryaprakash,Misra, Parimal,Vikramadithyan, Reeba K.,Rajagopalan
, p. 3265 - 3278 (2007/10/03)
Several thiazolidinediones having chroman moieties were synthesized and evaluated for their euglycemic and hypolipidemic activities. Some of the analogues having an aminoalkyl group as a linker between the chroman ring and 4-[5-(2,4-dioxo-1,3-thiazolidinyl)methyl]phenoxy moiety seem to be better than troglitazone. In vitro transactivation assays of PPARγ have been carried out with these glitazones to understand their molecular mechanism. For the first time we have found that some of the unsaturated thiazolidinediones are superior to their saturated counterpart in the in vivo assay. A more potent thiazolidinedione analogue than troglitazone is reported. Pharmacokinetic studies have shown that protection of the OH group in the chroman moiety leads to a decrease in metabolism, thereby resulting in a superior pharmacological profile.
Benzylidenethiazolidine derivatives and their use for the inhibition lipid peroxides
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, (2008/06/13)
Benzylidenethiazolidine compounds of formula (I): STR1 [in which R1, R2 and R5 are each hydrogen or alkyl; R3 and R4 are each hydrogen, alkyl, formyl, alkylcarbonyl, arylcarbonyl, carboxy, alkoxycarbo
