138572-73-3

Basic information

• Product Name: N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzamide
• Synonyms: N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzamide
• CAS NO: 138572-73-3
• Molecular Weight: 416.991
• Mol File: 138572-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzamide(138572-73-3)
• EPA Substance Registry System: N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzamide(138572-73-3)

Safety Data

• Hazardous Substances Data: 138572-73-3(Hazardous Substances Data)

Upstream product

• 125341-29-9 methyl 5-chloro-3-(3'-cyclohexenyl)salicylate 
• 138605-33-1 methyl 5-chloro-3-cyclohexyl-2-(1'-methallyloxy)benzoate 
• 125341-28-8 methyl 5-chloro-2-(3'-cyclohexenyl)salicylate 
• 138572-51-7 methyl 5-chloro-3-cyclohexylsalicylate 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 76883-48-2 quinuclidin-3-amine 
• 138572-70-0 5-Chloro-3-cyclohexyl-2-(1-methyl-allyloxy)-benzoic acid 

Relevant articles and documents

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

This report describes the development of novel benzamides which are orally active, highly potent, specific antagonists of 5-HT3 receptors. Described in this first report are the structure-activity relationships that led to novel structures with improved potency and selectivity. From this series of compounds, (S)-28 was identified and selected for further evaluation as a 5- HT3 receptor antagonist. Compared with 5-HT3 antagonists such as GR 38032F, BRL 43694, and metoclopramide, (S)-28 was most active in (a) inhibiting binding to 5-HT3 receptor binding sites in rat entorhinal cortex with an K(i) value of 0.19 nM and (b) blocking cisplatin-induced emesis in the ferret with an ED50 value determined to be 9 μg/kg po.