1385774-91-3

Basic information

• Product Name: (R,Z)-2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoic acid
• Synonyms: (R,Z)-2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoic acid
• CAS NO: 1385774-91-3
• Molecular Weight: 528.577
• Mol File: 1385774-91-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,Z)-2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R,Z)-2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoic acid(1385774-91-3)
• EPA Substance Registry System: (R,Z)-2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoic acid(1385774-91-3)

Safety Data

• Hazardous Substances Data: 1385774-91-3(Hazardous Substances Data)

Upstream product

• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 15125-84-5 ethyl 2-hydroxy-5-iodobenzoate 
• 1385774-96-8 C₁₁H₂₃NO₂S*ClH 
• 1385775-02-9 N-Boc-(L)-isobuytlcysteine tert-butyl ester 
• 1385774-90-2 (R,Z)-tert-butyl 2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoate 
• 1385774-87-7 (R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate 
• 1385774-84-4 N-allyl-2-(allyloxy)-5-(2-(2,4-difluorophenyl)ethynyl)benzamide 
• 1385774-83-3 ethyl 2-(allyloxy)-5-(2-(2,4-difluorophenyl)ethynyl)benzoate 
• 1385774-73-1 ethyl 5-(2-(2,4-difluorophenyl)ethynyl)-2-hydroxybenzoate 
• 873330-41-7 (R)-N-(tert-butyloxycarbonyl)-S-(isobutyl)cysteine 

Relevant articles and documents

Synthesis of conformationally constrained benzoylureas as BH3-mimetics

The design of small molecules that mimic the BH3 domain and bind to Bcl-2 proteins has emerged as a promising approach to discovering novel anti-cancer therapeutics. We reveal the design and synthesis of conformationally constrained benzoylurea scaffolds as conformational probes. Central to helix mimicry, the intramolecular hydrogen bond in the benzoylurea plays a key role in the pre-organisation of the acyclic substrates for cyclisation via ring closing metathesis, providing efficient access to the constrained mimetics. The Royal Society of Chemistry 2012.