1385787-07-4Relevant academic research and scientific papers
Synthesis of thymidine dimers from 5′-O-aminothymidine
Peyrat, Sandrine,Xie, Juan
experimental part, p. 1718 - 1724 (2012/08/08)
The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5-O-aminothymidine is reported. Georg Thieme Verlag Stuttgart · New York.
