138582-75-9

Upstream product

• 138582-73-7 (S)-3-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-N-(2-hydroxy-ethyl)-succinamic acid benzyl ester 
• 138566-38-8 Diisopropyl-phosphoramidous acid benzyl ester (2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-((2S,3S,4S,5R,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methoxy-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-ylmethyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF A PEPTIDYLDIMANNOSYL PHOSPHATE: FRAGMENT OF THE VARIANT-SPECIFIC SURFACE GLYCOPROTEIN MEMBRANE ANCHOR FROM TRYPANOSOMA BRUCEI

Condensation of protected β-benzyl-aspartate 4 with 2-amino-ethanol, subsequent deprotection of the amino function and coupling with N,N'-di-benzyloxycarbonyl-lysine (7) afforded the peptidyl alcohol 8.Glycosylation of methyl 3,4,6-tri-O-benzyl-α-D-mannopyranoside (11) by ethyl 2,6-di-O-benzoyl-3,4-di-O-benzyl-1-thio-α-D-mannopyranoside (14) gave, after debenzoylation and protection of the 2'-hydroxyl function, the suitably protected dimannoside 21.Phosphitylation of 21 with benzyloxy-bis-(N,N-diisopropylamino)phosphine (18) followed by the addition of 8 gave, after oxidation and subsequent hydrogenolysis of the benzyl groups, the title compound in a good yield.