138587-55-0Relevant academic research and scientific papers
Easy and General Synthesis of Unsymmetrical α-Halogeno Ketones
Barluenga, Jose,Llavona, Lujan,Yus, Miguel,Concellon, Jose M.
, p. 2890 (2007/10/02)
The reaction of carboxylic acid esters 1 with in situ generated bromohalomethyllithium (1:2 molar ratio) at -78 deg C followed by reaction with lithium dialkylcuprate (1:1 molar ratio) at 0 deg C, leads, after hydrolysis, to the corresponding α-chloro or α-bromo ketones 3.
