138588-19-9

Upstream product

• 138588-18-8 (4S,5S)-5-((1S,2S)-2-tert-Butylsulfanylcarbonyl-1-hydroxy-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 138588-17-7 ((1-(tert-butylthio)-3-methylbut-1-en-1-yl)oxy)trimethylsilane 
• 112190-41-7 (4R,5R)-4-Cyclohexylmethyl-5-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 129921-97-7 (4R,5S)-5-((1R,2S)-2-Butylcarbamoyl-1-hydroxy-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A Stereoselective Synthesis of Hydroxyethylene and erythro-Dihydroxyethylene Dipeptide Isosteres: A Facial Selective anti-Aldol Reaction

A Lewis-acid catalyzed anti-aldol reaction of aldehyde 4 afforded diol 6a (95percent de).Aminolysis of the corresponding β-lactone provided erythro-dihydroxyethylene dipeptide isostere 2 while the lactone-protected hydroxyethylene dipeptide isostere 3 was obtained through selective deoxygenation and acidic deprotection. Key words: hydroxyethylene isostere; anti-aldol; aspartic proteinase; renin inhibitor; facial selective